CBD FOR PETS

Breast Cancer treatment with cannabis; terpene clinical trials and more



Breast cancer research with cannabis and terpenes have shown that d-limonene, geraniol, and eucalyptol are the most useful terpenes. High CBD cannabis oil may also be the most effective. The TRPV1, TRPM7, and TRPM8 are the target receptors for breast cancer.

To learn more about making your own cannabis oil at home, and about how Rick Simpson cured his own cancer with cannabis; check out his books that are available on Amazon:

Phoenix Tears – The Rick Simpson Story – https://amzn.to/34CLTal

Rick Simpson Oil – Nature’s Answer for Cancer – https://amzn.to/2LwroVz

Sources:

Cho, M., So, I., Chun, J. N., & Jeon, J. H. (2016). The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review). International journal of oncology, 48(5), 1772–1782. doi:10.3892/ijo.2016.3427

Vigushin, David M. Poon, Grace K. Boddy, Alan. English, Jacqueline. Halbert, Gavin W. Pagonis, Christos. Jarman, Michael. Coombes, R. Charles. Cancer Research Campaign Phase I/II Clinical Trials Committee Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer
25 June 1997

Chodon, D., Guilbert, A., Dhennin-Duthille, I., Gautier, M., Telliez, M. S., Sevestre, H., & Ouadid-Ahidouch, H. (2010). Estrogen regulation of TRPM8 expression in breast cancer cells. BMC cancer, 10, 212. doi:10.1186/1471-2407-10-212

Yapa KTDS, Deuis J, Peters AA, Kenny PA, Roberts-Thomson SJ, Vetter I, Monteith GR. Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sci. 2018 Apr 1;198:128-135. doi: 10.1016/j.lfs.2018.02.030. Epub 2018 Feb 26.

Dechen Chodon, Arnaud Guilbert, Isabelle Dhennin-Duthille, Mathieu Gautier, Marie-Sophie Telliez, Henri Sevestre, Halima Ouadid-Ahidouch. Estrogen regulation of TRPM8 expression in breast cancer cells. BMC Cancer
volume 10, Article number: 212 (2010)

Yee N. S. (2015). Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion. Cancers, 7(4), 2134–2146. doi:10.3390/cancers7040882

Sun, Y., Sukumaran, P., Varma, A., Derry, S., Sahmoun, A. E., & Singh, B. B. (2014). Cholesterol-induced activation of TRPM7 regulates cell proliferation, migration, and viability of human prostate cells. Biochimica et biophysica acta, 1843(9), 1839–1850. doi:10.1016/j.bbamcr.2014.04.019

Jeroen Middelbeek, Arthur J. Kuipers, Linda Henneman, Daan Visser, Ilse Eidhof, Remco van Horssen, Bé Wieringa, Sander V. Canisius, Wilbert Zwart, Lodewyk F. Wessels, Fred C.G.J. Sweep, Peter Bult, Paul N. Span, Frank N. van Leeuwen and Kees Jalink. TRPM7 Is Required for Breast Tumor Cell Metastasis. Cancer Research: Tumor and Stem Cell Biology. DOI: 10.1158/0008-5472.CAN-11-3863 Published August 2012

Weber, L. V., Al-Refae, K., Wölk, G., Bonatz, G., Altmüller, J., Becker, C., … Hatt, H. (2016). Expression and functionality of TRPV1 in breast cancer cells. Breast cancer (Dove Medical Press), 8, 243–252. doi:10.2147/BCTT.S121610

Valero, M. L., Mello de Queiroz, F., Stühmer, W., Viana, F., & Pardo, L. A. (2012). TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. PloS one, 7(12), e51825. doi:10.1371/journal.pone.0051825

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